The Basic Principles Of modafinil norge
The Basic Principles Of modafinil norge
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Stiripentol is often a CYP3A4 inhibitor and inducer. Observe CYP3A4 substrates coadministered with stiripentol for enhanced or decreased effects. CYP3A4 substrates may well involve dosage adjustment.
cyclophosphamide will raise the degree or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.
modafinil will decrease the extent or outcome of fruquintinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration with reasonable CYP3A4 inducers is unavoidable, proceed to administer fruquintinib at encouraged dosage.
Minor (1)modafinil will improve the amount or result of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Small/Significance Mysterious. Web effect on pantoprazole actions not known as a result of opposing effects of CYP450 enzymes; keep track of
modafinil will minimize the extent or effect of copyright topical by influencing hepatic enzyme CYP2B6 metabolism. Small/Importance Unknown.
Check INR extra regularly if coadministered with inhibitors of such isoenzymes and regulate warfarin dose if wanted.
modafinil will enhance the degree or outcome of clobazam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Dosage adjustment could be expected; CYP2C19 inhibitors might end in greater exposure to N-desmethylclobazam (Energetic metabolite).
modafinil will minimize the extent or impact of levoketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
mitotane decreases amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is a powerful inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for probable dosage adjustments.
cenobamate will enhance the stage or influence of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Carefully. Take into consideration a dose reduction of CYP2C19 substrates, as clinically suitable, when employed concomitantly with cenobamate.
fosphenytoin will lower the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Warfarin's a lot less strong R-enantiomer is metabolized in part by CYP3A4 (and in addition CYP1A2 and CYP2C19). Watch INR additional commonly if coadministered with inhibitors of those isoenzymes and modify warfarin dose if required.
In case you are allergic to modafinil; any part of this medication; or another prescription drugs, foods, or substances. Explain to your physician regarding the allergy and what indicators you had.
On the other hand, this only implies that it is fairly safer than other medications: it does not necessarily mean click here that modafinil is solely without having challenges.